Volume 13 | Issue 2 |

 Abstract

Head and neck cancers (HNC) contribute significantly to the global cancer burden, with high incidence rates in India. Patients with HNC often experience substantial psychosocial distress, including depression and anxiety, which negatively affect their quality of life and treatment outcomes.

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 Keywords

Head and neck cancer, Psychosocial distress, Radiation therapy, Depression, Anxiety, Quality of life.

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 Abstract

Abstract :- Saline vegetation are common in rajasthan specially western part of rajasthan. Salinity associated with drought is severe ecological threat in the western part of rajasthan which is recognised as Thar desert. The Halophytic plants are widely distributed throughout several reasons of the western part due to their saline extent such as Lunkaransar, khajuwala, chhatargarh, panchbhadra etc. But some Eastern part of rajasthan is also included in saline extent such as Nawa, Didwana, sambhar, raiwasa etc. The saline land and arid or semi arid zones are promising foodstuff alternative for animals. Some common Halophytic plants are present in saline area such as Salsola, Sueda, Heloxylon, Trianthema, Portulaca, Tamarix, Salvedora and some grasses.

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Keyword :- Halophytes of Raiwasa lake

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In recent years, libraries have experienced a dramatic change, switching from manual to automated procedures. This study examines the development of library automation, including its essential elements, advantages, difficulties, and potential developments. It looks at how automation has boosted productivity for both librarians and patrons, improved information access, and improved library services. The impact of new technologies like machine learning and artificial intelligence on library automation is also covered in the study, as is how they could further transform library services in the years to come.

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Library automation, Automated library systems, Library technology, Library services, Library management, Technological advancements in libraries.

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The key object of this present research study is preparation and evaluation of a polyherbal Shampoo to determine physiochemical function that emphasises on safety, Efficacy and quality of the product. Herbal Shampoo is the natural haircare product Which is use to remove oil, dirt, dandruff and stimulate hair growth, Strenthness and darkness of the hair. It is also supply softness, silkiness, and Shines for the hair. The herbal active ingredients and their uses in hair activity, and used in the preparation of shampoo and they are shikakai, reetha, amla, neem, aloe-vera, onion, garlic, gaur gum. Prepared polyherbal shampoo have evaluated parameters of polyherbal shampoos such as physical appearance, PH determination, determination of percentage solid content, foam stability test, viscosity test , skin irritation test, stability study, antimicrobial activity was performed and we found that the prepared polyherbal shampoo has key beneficial effect for hair.

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Herbal shampoo, Strenthness, Darkness, Amla.

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This study aims at analyzing the efficiency of a relatively new and promising marketing strategy influencer marketing to explain consumers' behaviour, build brand familiarity and create purchase intentions. Using metrics and consumers' responses, the work displays how influencers assist in enhancing brand credibility and trust. It highlights that endorsement from influencers matter where consumers spending their time and spending their money socially, especially digital natives. Further, the study looks at these two factors, namely the content authenticity and the appropriate platform in achieving highest campaign outcome. The findings highlight the role of identifying proper influencers for cooperation, as well as explore the ways of achieving increased marketing performance and consumers' loyalty.

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Influencer Marketing, Consumer Behaviour, Brand Awareness, Purchase Intentions, Digital Engagement.

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 Abstract

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KRAS is the most frequently mutated oncogene in lung carcinomas, accounting for 25% of total incidence, with half of them being KRASG12C mutations. RAS is one of the most well-known protooncogenes.

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Cancer; EGFR, KRAS, mutations, targeted-therapy

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Transdermal patches are a non-invasive drug delivery system designed to deliver medications through the skin directly into the bloodstream, offering an alternative to oral and injectable routes. This method provides sustained and controlled release of drugs, potentially enhancing therapeutic efficacy and patient compliance. This paper reviews the mechanisms of transdermal delivery, the types of drugs suitable for this route, the design and development of transdermal patches, and the advantages and challenges associated with their use. Current advancements in technology and materials, as well as future directions for research and development, are also discussed. Purpose: Transdermal patches deliver medication more directly to the bloodstream by by passing processing in the liver. Transdermal patches deliver medication over a longer period of time than traditional systems, which can be easier on patients who experience extreme side effects. Method: The process of solvent casting can be utilized for manufacturing Transdermal patch utilizing polymers such as HPMC , PVPK-30 and Eudragit L-100. The ratio of chloroform to mthanol employed as a solvent was 5:5. The mechanical stirrer's speed was 500 rpm. Result: Among the various formulations evaluated, batch F4 emerged as the most suitable choice for preparing Etodolac Transdermal patch. This particular formulation contains 50% (w/w) Pvpk-30 and 17% (w/w) PEG 400, which have proven to be effective in achieving the desired outcomes. The F-4 formulation exhibited good organoleptic properties and a folding endurance of 5, indicating its durability during handling. In-vitro dissolution studies demonstrated a rapid drug release rate of 97.66% within 8 hr, while the patch disintegrated in just 8 hr. These findings highlight the significant potential of utilizing polymers like Hpmc, Pvpk-30 and Eudragit L-100 for the development of highly effective and patient-friendly Transdermal drug delivery systems. Conclusion: The research indicates that utilizing the solvent casting process with HPMC , PVPK-30 and Eudragit L-100 to create Transdermal patch containing Etodolac is an acceptable method.

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Transdermal patch , Transdermal drug delivery system , Skin, Matrix, Reservoir, Systemic circulation, routes of penetration.

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This report presents an in-depth exploration of image segmentation techniques, focusing on Gaussian Mixture Models (GMM) and their comparison with K-Means clustering and Otsu's Thresholding. Image segmentation is a crucial process in computer vision, widely used in applications such as medical imaging, object detection, and autonomous navigation. Gaussian Mixture Models (GMM) provide a probabilistic approach to segmentation, effectively modelling complex distributions within an image. By utilizing multiple Gaussian distributions, GMM can distinguish different regions based on their pixel intensity distributions, making it highly effective for images with overlapping clusters or multi-modal intensity distributions. However, this method comes with a computational cost, as it requires iterative Expectation-Maximization (EM) optimization, which can be slower compared to other clustering methods. This study highlights the flexibility of GMM in handling complex distributions, its trade-off with computational efficiency, the practicality of K-Means for quick clustering, and the simplicity of Otsu's method for threshold-based segmentation. Experimental results demonstrate the effectiveness of these techniques in segmenting images, providing insights into their practical applications, strengths, and limitations. The comparative analysis offers guidance on selecting the appropriate segmentation technique based on specific application requirements.

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-- Image Segmentation, Gaussian Mixture Model (GMM), K-Means Clustering, Otsu's Thresholding, Expectation-Maximization (EM), Computer Vision, Pixel Classification, Probabilistic Modelling, Feature Extraction

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Work-life balance has emerged as a critical factor in stress management, particularly in the dynamic and fast-paced environment of the IT sector. The rapid technological advancements, high workload, tight deadlines, and constant demand for innovation often lead to significant stress among IT professionals. This study explores the role of work-life balance in mitigating stress and improving overall well-being in the IT sector. It examines the impact of organizational policies, flexible work arrangements, and individual strategies on stress levels. The research employs an approach, combining quantitative surveys to gather information from IT employees at different organizational levels. The findings reveal that achieving work-life balance significantly reduces stress and enhances job satisfaction, productivity, and mental health. Organizational interventions, such as remote work options, wellness programs, and realistic workload expectations, are identified as essential enablers. Personal factors, including time management, setting boundaries, and prioritizing self-care, are highlighted as vital for stress management. The study underscores the importance of creating a supportive work culture that fosters work-life balance and equips employees with tools to manage stress effectively. It contributes to the existing body of knowledge by providing information for HR managers, organizational leaders, and policymakers to design strategies promoting employee well-being in the IT sector.

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 Keywords

Work-life balance, Stress Management, IT sector, Employee well-being, Flexible work arrangements, organizational policies, productivity, mental health.

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Creative Commons Attribution 4.0 and The Open Definition