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DEVELOPMENT AND IN VITRO EVALUATION OF ANTI-ACNE GEL CONTAINING PSIDIUM GUAJAVA LEAF EXTRACT
Authors
Ms. Snehal V. Sonawale,Ms. Ankita R. Chougale,Mr. Rajanikant B. Ghotane
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Keywords
Anti-acne gel, Psidium guajava, Guava leaf extract, Acne vulgaris, Carbopol 934, Herbal formulation, Antimicrobial activity, Cutibacterium acnes, Topical drug delivery, Phytochemical screening
Abstract
Acne vulgaris is a common chronic inflammatory skin disorder affecting the pilosebaceous unit and is associated with microbial infection, excess sebum production, and inflammation. The present study focuses on the development and in vitro evaluation of an anti-acne gel formulated using Psidium guajava (guava) leaf extract, known for its antimicrobial, antioxidant, and anti-inflammatory properties.
The guava leaves were collected, authenticated, shade-dried, and subjected to hydroalcoholic extraction using the maceration technique. Preliminary phytochemical screening confirmed the presence of bioactive constituents such as flavonoids, tannins, and phenolic compounds. The extract was incorporated into a gel base using Carbopol 934 to prepare three formulations (F1, F2, and F3) with varying concentrations of the extract.
The formulated gels were evaluated for physicochemical parameters including physical appearance, pH, spreadability, viscosity, washability, and stability. All formulations showed acceptable organoleptic properties, with pH in the range suitable for skin application (6.0-7.0). Spreadability and viscosity studies indicated that formulation F1 exhibited optimal performance with good consistency and ease of application. Stability studies revealed that F1 remained stable under both room temperature and refrigerated conditions, while F2 and F3 showed moderate variations.
The antimicrobial activity was evaluated against Cutibacterium acnes using the agar well diffusion method. The formulation exhibited minimal antibacterial activity compared to the standard drug, indicating the need for further optimization.
In conclusion, the study demonstrates that Psidium guajava leaf extract can be successfully formulated into a topical gel with acceptable physicochemical properties, though enhancement of antimicrobial efficacy is required for improved therapeutic potential.
IJCRT's Publication Details
Unique Identification Number - IJCRT2605285
Paper ID - 307976
Author type - Indian Author
Page Number(s) - c379-c394
Pubished in - Volume 14 | Issue 5 | May 2026
DOI (Digital Object Identifier) -
No Of Downloads - 36
Author Country - India, 416112, Kolhapur, Kolhapur, 416112, Pharmacy All
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
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Ms. Snehal V. Sonawale,Ms. Ankita R. Chougale,Mr. Rajanikant B. Ghotane, "DEVELOPMENT AND IN VITRO EVALUATION OF ANTI-ACNE GEL CONTAINING PSIDIUM GUAJAVA LEAF EXTRACT", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.14, Issue 5, pp.c379-c394, May 2026, Available at :http://www.ijcrt.org/papers/IJCRT2605285.pdf
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