Volume 10 | Issue 1 |

 Abstract

The indole analogues were investigated for the electrochemical behavior using the glassy carbon electrode as the working electrode. In the present study electrochemical reduction or oxidation of indole analogues in sulphuric acid media was reported. We can see that the C=N functional groups in the molecule is easily reduced at the glassy carbon electrode. These compounds were also subjected to DNA cleavage study. In this study Compounds 1a-c have shown highest activity and remaining compounds shown moderate activity. Compounds with halogen, methyl substitution at five positions and phenyl ring at third position of indole nucleus have exhibited very good activity when compared to standard.

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 Keywords

Indole, Carbohydrazide, DNA Cleavage activity, Cyclicvoltametry

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 Abstract

The traditional sign & symptoms of Kampavata resembles with modern day's Parkinson's disease.kampavata is the one of Namatamja vata vikara explained in texts of Ayurvedic samhitas.Parkinson's disease is a degenerative disorder of central nervous system and is having pathology in substantia nigra & is extra-pyramidal crippling disease.Parkinson's disease affects 1% of population above the age of 50 years.The symptoms of kampavata are hasta-padyo kampa( tremors in hands and legs),stambha(rigidity),chests sanghat(Bradikinesia and akinesia) vakvikruti(disturbance in speech) and gatra sanghat( postural abnormality).In spite of advancement in the field of modern medical science the treatment of this disease remains symptomatic only and no complete cure is available till date.The motor features of Parkinson's disease can be managed with treatment that replaced the chemical dopamine in the brain.while there is many medically approved dopamine replacement drugs available for patients affected by Parkinson's disease there also many natural sources.The previous research on mucuna pruriens are supported as one of the most potent natural source of dopamine replacement treatment.

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kampavata, Mucuna pruriens beej, Mucuna pruriens beej matra basti , parkinson's disease

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 Abstract

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Life Satisfaction, Mental Health, Working and non working mothers.

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Fair is integral part of rural Economy . It is a tradition and cultural part and entertainment of rural peoples. They have in this vational period of Agriculture, but it is a one ofthe Economic activities for the rural peoples. India is a developing countries , 72.18 percent of population livening in rural areas. Agriculture is main activities of people. Because the vocational period of Agriculture , the create a different cultural activities , and thereinto , they have enjoyed. In these activities are held world wide, including in India. In Mysuru district has different cultural Faires. It is located in different place and different period. The present study is designed to explain the Fairs of Mysuru district as periodic marketing institution and also their significant characteristics.

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location of Fairs. Historical, Economical,and Geographical, Types. periodcity

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ABSTRACT Angiotensin converting enzyme 2 (ACE2) is a transmembrane protein which is considered as a receptor for spike protein binding of novel corona virus (SARS-CoV2). Since no specific medication is available to treat COVID-19, designing of new drug is important and essential. In this regard, this study was to seek potential natural compounds that can resist COVID-19 using in silico molecular docking on ACE2 proteins. Molecular docking was achieved by using the Argus lab software. Natural products are safe and easily available to treat corona virus affected patients, in the present alarming situation. The natural phytocompounds acting on spike protein of SARS-CoV2 with its human receptor ACE2 molecule were then selected from siddha medicine one of the traditional systems of India Sundaikai vattral Choornam (Solanum torvum) have valuable properties of cold, cough, tuberculosis, hepatotoxicity, cancer, etc. Results: eight potential natural anti-COVID-19 phytocompounds were selected and were evaluated for absorption, distribution, metabolism and excretion (ADME) and Lipinski rules. The content of the eleven phytocompounds from Solanum torvum were determined via a literature search. Conclusion: Solanum torvum show promise for resisting COVID-19 and are thus recommended as supplements to prevent the infection of COVID-19 during its outbreak period.

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In silico, Solanum torvum, COVID-19, Argus Lab, phytocompounds, SARS-CoV2 and ACE2.

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Climate change has been a universal truth of life. The present paper throws a light on the need of containment of climate change which has become imperative on immediate basis. We need to act urgently if we are to avoid an irreversible buildup of greenhouse gases and global warming at a potentially huge cost to the economy and society worldwide the constant consequences of inaction on global warming will continue to grow more and more costly overtime. This paper discusses various strategies and institutions that have contributed to minimizing the anthropogenic climate change and its effects.

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Climate ,Temperature, Sustainability ,Resources

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Standardization, herbal drug, DNA fingerprinting, chromatographic techniques

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In this present study we have documented the list of exotic plant species found from Saraswati Degree Science College Campus and adjoining areas in Bhawanipatna, Kalahandi district, Odisha with additional information on habit, origin and uses. During the study, a total of 25 exotic species belonging to 25 genera in 20 families were identified and listed. Among them 12 number of exotic species are native to Trop. America followed by Mexico with three species, Brazil with two species. Analysis of the habit shows that herbs having 17 (68%), followed by (05) 20% shrubs and (03) 12% trees. Among 20 families, Amaranthaceae is dominant family with three species followed by three families i.e. Asteraceae, Euphorbiaceae and Malvaceae with two species each, while rest 16 families contribute one species each. There is an urgent need to catalog the regional data on exotic species in order to study the impact on local vegetation.

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Exotic species, nativity, Bhawanipatna, Kalahandi, Odisha

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A Study on Awareness of Secondary School Students on Effects of tobacco smoke towards public health

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ABSTRACT Coronavirus pandemic has been one of the greatest general wellbeing crises for humankind. The sickness is brought about by SARS-CoV-2 strain of Covid. Transmission of the infection is known to happen through close contact with a tainted individual or from debased surfaces. The infection can likewise be communicated from one individual to another in the pre-suggestive stage and from asymptomatic people. Pregnancy doesn't expand helplessness to SARS-CoV-2 disease yet seems to demolish the clinical course of COVID-19 contrasted and non-pregnant ladies of a similar age. With respect to vertical transmission, arising proof currently recommends that upward transmission is likely, albeit the extent of pregnancies impacted and the importance to the youngster presently can't seem not really settled. The recurrence of unsuccessful labor doesn't have all the earmarks of being expanded, yet information on first and second trimester contaminations are restricted. Analysis of information from PW with affirmed or suspected COVID-19 contamination from 12 nations, announced still rates of birth of 0.4 to 0.6 percent, which have all the earmarks of resembling public populace-based information. Steady treatment incorporate rest, oxygen supplementation, liquid administration and dietary consideration,Hydroxychloroquine in a portion of 600 mg (200 mg threefold every day with suppers) and Azithromycin (500 mg one time each day) for 10 days,Against viral Therapy Lopinavir-ritonavir, Remdesivir, Oseltamavir. Close consideration was paid the respiratory status of tainted pregnant ladies, like hack recurrence, sputum properties, and indications of dyspnea. Birthing assistants and medical caretakers ought to urge ladies to perform profound breathing, help them turn, and perform standard chest percussion meetings to relax lung blockage and increment the lady's capacity to clear sputum. Direction to date suggests that pregnant ladies with affirmed or suspected COVID-19 ought to be isolated for 14 days.

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 Keywords

covid,pregnancy,virus,transmission

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Creative Commons Attribution 4.0 and The Open Definition