Volume 13 | Issue 9 |

 Abstract

Cancer is a complex and multifaceted disease characterized by the uncontrolled growth and spread of abnormal cells. It can affect any part of the body and is a leading cause of death worldwide. Breast cancer is a disease in which malignant cells form in the tissues of the breast, often originating in the ducts or lobules. It is one of the most common types of cancer affecting the women worldwide. Lot of conventional therapies are available for the treatment of cancer, but the main problem associated with the treatment is the occurrence of serious adverse effects. Plants play a vital role in the discovery and development of anticancer agents due to their rich diversity of bioactive compounds with therapeutic potential. Many plant-derived secondary metabolites, such as alkaloids, flavonoids, and terpenoids, exhibit strong anticancer properties by targeting multiple cellular pathways involved in cancer development, including apoptosis induction, inhibition of angiogenesis, and suppression of metastasis. Network pharmacology is an emerging and highly relevant approach in modern drug discovery, especially for complex diseases like cancer. Unlike traditional "one drug, one target" strategies, network pharmacology embraces the complexity of biological systems by examining how drugs interact with multiple targets and pathways simultaneously. Viola tricolor, commonly known as wild pansy, heartsease, or Johnny jump-up, is a small annual or perennial herbaceous plant from the Violaceae family, native to Europe and parts of Asia. Phytochemical studies have identified a rich profile of bioactive compounds in Viola tricolor, including flavonoids (violanthin, rutin), phenolic acids (Caffeic and p-Coumaric acids), cyclotides, saponins, and carotenoids, which contribute to its wide spectrum of pharmacological activities. Recent in vitro studies have demonstrated that extracts of Viola tricolor exhibit cytotoxic effects against various cancer cell lines, including human cervical (HeLa), breast (MCF-7), and lung carcinoma cells, indicating potential anticancer activity. Due to its multi-component composition and traditional medicinal relevance, Viola tricolor is increasingly being studied through network pharmacology and molecular docking approaches to better understand its potential as a natural source of anticancer agents. The study utilized a network pharmacology approach to explore the anticancer potential of Viola tricolor, uncovering its multi-target and multi-pathway therapeutic actions. The analysis revealed that bioactive compounds in Viola tricolor interact with key cancer-related proteins such as TP53, PIK3CA, AKT1, JAK2, and ERBB2, which are central nodes in critical signaling pathways governing cell proliferation, apoptosis, and metastasis.

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UNVEILING THE ANTICANCER POTENTIAL OF Viola tricolor: A NETWORK PHARMACOLOGY APPROACH

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Abstract: One of the salient features of Dr. A.P.J. Abdul Kalam's autobiography Wings of Fire is the theme of mentoring. In this book, the author narrates his journey from childhood to becoming the 'Missile Man of India' and eventually the President of the nation. He highlights the contributions of several mentors who significantly shaped his personality, values, and outlook on life. These mentors include his father Jainulabdeen, mother Ashiamma, cousin Jalaluddin, Samsuddin, Pakshi Lakshmana Shastry, Rev. Fr. Eudurai Solomon, Father T.N. Sequeira, Prof. Srinivasan (then Director of MIT), Prof. Vikram Sarabhai, Dr. Brahm Prakash, among others. Their guidance, combined with his own perseverance and hard work, played a crucial role in his rise to become an eminent aerospace scientist.

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Keywords: personality, outlook, life, character, career, guidance, hard work

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Ayurveda and Yoga are two ancient and best practices that have been used for centuries to promote physical, mental and spiritual health. Both Ayurveda and Yoga originated in India and have same Vedic roots. Yoga is very well known for its contribution in prevention of various lifestyle diseases such as Obesity, Diabetes Mellitus, Atherosclerosis etc. But when it comes to Surgical diseases, contribution of Yoga is the topic which is very least talked about. Yoga can play a significant role in managing various surgical diseases, particularly in reducing anxiety, pain and improving overall well-being of a person. Many research suggests that yoga can impact positively impact preoperative, postoperative outcomes and also can fasten wound healing which results in reduced hospital stays for patients. This article will highlight common surgical cases in which specific Yoga can prove helpful in many aspects such as reducing pain, preventive measures etc.

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Ayurveda, Yoga, Surgical diseases

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Profitability is the life blood of every business. The term profitability includes two terms profit and ability. Every business organisation wants to know its profit at the end of the year. It also wants to know its profit earning capability. Ultimate profit comes from the profit earning capability of the company or Industry. Tea is an industry of two folds values. It has industrial value and also it has agricultural value. The present study aims to identify the comparative profitability performance and weaknesses of selected tea companies in West Bengal. The study covers 10 tea companies operating in West Bengal. Out of which 6 are public sector tea companies and 4 are private sector tea companies. The study has been undertaken for the period of twelve years from 2014 to 2025. To analyse the comparative profitability of selected public sector and private sector tea companies, various accounting ratios have been used. Various statistical tools such as A.M., S.D., C.V., have been used to measure the comparative profitability and t-test has been used to test of significance.

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Profitability Analysis, Public Sector Tea Company, Private Sector Tea Company, Descriptive Statistics, t-test, Comparative Study

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Murraya paniculata (Rutaceae), commonly known as orange jasmine, is an evergreen shrub of considerable medicinal and economic importance. Members of the Rutaceae family are widely recognized for their edible fruits and essential oils, while M. paniculata has gained attention for its diverse pharmacological activities. Literature on the pharmacognostic features, phytochemical composition, and ethnomedicinal uses of M. paniculata was reviewed from various scientific databases. Reports indicate that its leaf extracts contain phenolic compounds, oxygenated flavonoids, flavanones, sesquiterpenoids, polymethoxy glycosides, and coumarins. Essential oils are rich in cyclocitral, methyl salicylate, trans-nerolidol, cubenol, isogermacrene, cadinol, and cubeb-11-ene. Traditional medicine describes the therapeutic use of its bark, leaves, and flowers. Pharmacological studies confirm multiple biological properties, including anti-diabetic, anti-obesity, antibacterial, antioxidant, anti-implantation, cytotoxic, anti-diarrheal, antidepressant, and anxiolytic effects. The wide spectrum of activities suggests its potential as a source of novel therapeutic agents. Murraya paniculata exhibits remarkable pharmacognostic and phytopharmacological potential. Further scientific investigations focusing on its active constituents may contribute to the development of new drugs for managing infectious and metabolic disorders, thereby expanding its clinical relevance.

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Herbal plants, Murraya paniculata, Pharmacognosy, Therapeutic uses.

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 Abstract

Chatro Ki Suraksha Aur Shashtikaran Ke Liye Aatmaraksha Kaushal Ke Mahatva Ka Adhyan

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Chatro Ki Suraksha Aur Shashtikaran Ke Liye Aatmaraksha Kaushal Ke Mahatva Ka Adhyan

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Observation is a crucial aspect of case taking in homeopathy, allowing physicians to gather comprehensive information about a patient's physical, emotional, and mental state. This article highlights the importance of observation in homeopathic case taking, its key aspects, insights from homeopathic stalwarts, best practices, and impact on prescribing decisions.

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Homeopathy,Casetaking,Observations,Non-verbal cues Behavioral patterns, Physical characteristics, Emotional responses,Prescribing decisions, Remedy selection

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ABSTRACT Both industrialized and emerging nations are beginning to recognize the significance of the problem of economic inequality. By looking into this particular matter, the purpose of this study is to answer the question, "Does the correlation between income inequality and GDP growth vary with stage of development?" This is the question that this research intends to address. According to the findings of our sample of twenty nations, ten of which are developed and ten of which are developing, spanning the years 2000 to 2020, income inequality is a barrier to economic advancement all over the globe. On the other hand, it is rising countries that are feeling the effect far more intensely. Based on the findings of our study, we can conclude that the link between income inequality and economic development is not linear. This is because the negative impact of income disparity on economic growth grows exponentially worse beyond a certain level. An additional argument in favor of the non-linear nature of the connection is provided by this. Due to the fact that the threshold for vulnerability is lower in developing countries than it is in industrialized nations, vulnerability is more likely to occur in conditions that are less economically developed. There will be significant repercussions for public policy as a consequence of the findings, which indicate that developing countries, in particular, should make efforts to reduce income inequality if they want to foster sustainable economic growth.

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Keywords: Comparative Analysis, Developed and Developing Countries, Economic Growth, and Income Inequality

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ABSTRACT Our goal in doing this study is to learn how Foreign Direct Investment (FDI) affects job creation in developing countries by looking at both quantitative and qualitative indicators of labor market outcomes. Foreign direct investment (FDI) affects wage structures, job creation, and skill development across a number of industries; this research uses empirical data and theoretical frameworks to examine these effects. Management expertise, technology transfer, and access to global markets are a few ways in which foreign direct investment (FDI) may positively affect employment. Foreign direct investment (FDI) may have positive effects on economies, but it can also have negative consequences, such as job losses and pay inequality. For the purpose of identifying where FDI is most effective in generating employment opportunities, we examine regional and industry trends. A number of contextual elements are included in the research. These include human capital development, labor market flexibility, regulatory frameworks, and institution quality. How well foreign direct investment (FDI) creates long-term employment possibilities is affected by these variables. To help developing nations attract foreign direct investment (FDI) that will promote long-term economic development, this research offers practical insights into promoting inclusive growth, reducing unemployment, and improving the labor market overall. Cutting the unemployment rate would do this. It does this by highlighting legislative initiatives and exemplary practices.

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Keywords: Foreign Direct Investment (FDI), Employment Generation, Job Creation, Emerging Economies, Labor Market Outcomes, Wage Effects

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A socioeconomic study was conducted in the two mangroves of Cameroon with the objective of all the activities and livelihoods of populations and subsequently record their impact on the conservation and sustainable management of this ecosystem. The Rio Del Rey mangrove in the South-west region (Bakassi area) and the Cameroon estuary mangrove in the Douala region, include seven species that form the wood and non-wood floristic base in this environment. These comprise six indigenous mangroves species and one species introduced from Asia, the Nipa identifying palm (Nypa fructicans). The study underlines a multitude of sectors including those of halieutic (fishing) products, agricultural products, wood, shopkeeping and sand. Measures to manage the anarchic development of Nipa palm are suggested. For a sustainable management policy of Cameroonian mangroves, it is urgent to have laws and regulations specific to that ecosystem.

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 Keywords

mangroves, livelihoods, conservation, sustainable management, A socioeconomic study

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