Volume 13 | Issue 9 |

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Chitta-Pras?dana, Yoga Sutras, Conflict Resolution, Polarization, Emotional Regulation, Mindfulness

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The multi-target effects of bioactive compounds and their therapeutic potential are well explained by a network pharmacology framework. Computational network pharmacology methods were applied in this research to evaluate Scaevola taccada leaf extract's wound-healing activity. The GC-MS analysis identified a total of 20 active phytoconstituents, and Lipinski's rule was applied to filter for drug-likeness. 192 target-identified relevant genes were contrasted with 5,482 wound healing-related genes retrieved from the GeneCards database. 86 overlapping targets were determined through Venn analysis and are considered to be candidate therapeutic targets for wound healing. Essential hub genes were obtained through protein-protein interaction (PPI) analysis and included PPARG, ESR1, HIF1A, and MAPK1 as being essential regulators. GO enrichment analysis identified their involvement in inflammation, proliferation, and tissue remodelling through significant roles in nuclear receptor activation, transcription factor binding, and cell migration. Participation of putative targets in significant pathways like estrogen signaling, HIF-1 signaling, MAPK signaling, and regulation of lipid/atherosclerosis was again confirmed by KEGG pathway enrichment. The complex interaction between phytochemicals and molecular targets was demonstrated by the compound-target-pathway network constructed with Cytoscape. All of these findings indicate the prospective use of Scaevola taccada as a natural medicinal compound by showing it to modulate multi-gene and multi-pathway interactions to achieve wound-healing effects. This article emphasizes the employment of network pharmacology in validating traditional medicinal herbs for modern drug discovery, aside from providing molecular evidence for the pharmacological basis of Scaevola taccada

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network pharmacology, Scaevola taccada, wound healing, genes, molecular targets.

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This study investigates the intersection of hermeneutics with the ethical frameworks of Jainism and Hinduism, with a focus on their relevance to contemporary environmental sustainability discourse. Employing a hermeneutic methodology, the study interprets verses from foundational texts of these two Indian religious traditions to extract principles conducive to ecological sustainability. Central concepts such as non-violence, religious duties and sacredness of nature have been examined through interpretive lenses to uncover their ecological significance. Through an examination of religious verses, this paper highlights the contributions of these religions to modern sustainability practices. This paper explores how the ancient Indian traditions of Jainism and Hinduism provide ethical, and practical frameworks that align with the principles of sustainable development. By examining these traditions not merely as repositories of spiritual belief, but as dynamic systems of ecological ethics, the study seeks to contribute to the growing interdisciplinary dialogue between religion, philosophy, and environmental studies. The study proposes that religious literacy should be enhanced in terms of its significance for environmental conservation thereby proposing a pathway of environmental sustainability grounded in ethical worldviews, demonstrating how ancient religious philosophies can inform and enrich contemporary sustainability paradigms.

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Jainism, Hinduism, Environment, Sustainability, Interdependence

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Nasal drug delivery system having a numerous benefits, including quick immersion, avoiding first-pass metabolism, and non-invasive administration, hence drawn a lot of attention. A introduction to nasal deconstruction and physiology is given in this review, along with a discussion of the variables affecting medicine immersion and bioavailability. The convenience of administration and bettered patient compliance are impoetant in the design of the nasal medicine delivery system, which remains the favoured route of medicine delivery in malignancy of colorful disadvantages. Remedy through intranasal administration has been an accepted form of treatment in the Ayurvedic system of Indian Medicine. Nasal medicine delivery has been around for centuries and employed both rest and recreation, and also for the treatment of colorful conditions such as migraine, decongestion, and in exigency. The route is accessible and popular. It has multitudinous advantages similar to direct delivery to the (Central Nervous System) CNS, high bioavailability, needles aren't used , and no special chops are needed to delivery the medicine.

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Nasopulmonary,Physiology,Absorption,Deconstruction,CNS,Bioavailability.

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The nurturing of a child in a woman's womb occurs in a space untouched by bias or hierarchy. Yet, once gender is ascertained, discrimination and subordination begin to unfold, giving rise to socially constructed notions of masculinity and femininity. Violence against women and the systematic denial of their freedom under patriarchal dominance transcend barriers of class, caste, and religion, demonstrating that gender inequality is a deeply ingrained social reality. Central to women's liberation is the assertion of individuality and the insistence on acknowledgment. Within this context, Meghna Pant, an acclaimed voice in contemporary Indian feminist literature, through her novel One and a Half Wife, portrays the manifold hardships experienced by her protagonist within the domains of family and society. The protagonist's awakening of an inner consciousness and her defiance of imposed restrictions not only reveal the intricacies of women's lived realities but also provide a powerful model of inspiration for those bound within suffocating marital frameworks. This study, therefore, aims to acquaint the pangs and difficulties through which the protagonist resists repression rooted in patriarchal traditions and rigid belief systems, with specific emphasis on the narrative techniques employed by the author, Meghna Pant.

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Patriarchal, Suppression, Feminism, Self-recognition, Subjugation

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Background: Felodipine, a calcium channel blocker, suffers from poor aqueous solubility and limited oral bioavailability, which restricts its therapeutic efficacy. To overcome these limitations, nanoparticle-based delivery systems provide a promising approach for enhancing solubility, stability, and sustained release. Methods: Felodipine-loaded polymeric nanoparticles were prepared using the nanoprecipitation method with PLGA as the polymer and PVA as the stabilizer. Preformulation studies, including organoleptic evaluation, FTIR, ?max determination, melting point, solubility, partition coefficient, and drug excipient compatibility, were carried out. The formulations (F1-F5) were characterized for physical appearance, particle size, zeta potential, SEM morphology, pH, drug content, entrapment efficiency, in vitro drug release, and stability studies under ICH conditions. Results: Preformulation confirmed drug identity, purity, and lipophilic character (log P = 4.1). The prepared nanoparticles exhibited uniform, milky dispersions with particle sizes in the range of 234-254 nm. Formulation F4 showed optimal stability with a zeta potential of -13.7 mV, spherical morphology, and high entrapment efficiency (86.4%). In vitro release studies revealed sustained drug release, with F4 showing maximum release (92.9% over 8 hours) following zero-order kinetics. Stability testing confirmed no significant changes in drug content, pH, or release profile after three months at accelerated conditions. Conclusion: Felodipine-loaded PLGA nanoparticles, particularly formulation F4, demonstrated favorable physicochemical characteristics, enhanced entrapment, controlled release, and stability. This delivery system offers a promising strategy to improve the solubility, bioavailability, and therapeutic efficacy of Felodipine compared to conventional formulations.

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Felodipine, Polymeric Nanoparticles, PLGA, Nanoprecipitation, Controlled Release, Oral Bioavailability

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A total of 108 samples of working physiotherapist were taken , ipaq-sf questionnaires and oldenburg burnout inventory scale were distributed and data was analysed by spss software There was no significant correlation between physical activity level and occupational burnout in physiotherapists

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Occupational Burnout, ipaq-sf, hepa (health enhanced physical activity

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Pharmaceuticals can acquire impurities during different phases of their development, transportation, and storage, rendering them potentially hazardous for administration. Therefore, it is essential to identify and quantify these impurities. In this context, analytical instrumentation and methodologies are crucial. It has been demonstrated that sophisticated analytical methods for ensuring pharmaceutical quality have significantly transformed public health and contributed to the ongoing enhancement of healthcare delivery. This review emphasizes the most recent analytical techniques, such as mass spectrometry (MS), spectroscopy and chromatography method aimed at enhancing drug quality. These methods are used in quality control laboratories to ensure the identity, purity, safety, efficacy and performance of drug products

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Drug quality control, Pharmaceutical analysis, Analytical techniques, Quality Assurance

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This case study examines the management and clinical outcomes of a 59-year-old male diagnosed with multiple myeloma, a rapidly progressing hematologic malignancy. After completing several cycles of chemotherapy, the patient achieved remission and was recommended for an autologous bone marrow transplant (BMT). The pre-transplant conditioning regimen included stem cell collection, high-dose chemotherapy, and subsequent stem cell infusion. The patient was closely monitored for common post-transplant complications, including infection, graft-versus-host disease (GVHD), and mucositis. Following a successful engraftment phase and appropriate supportive care, the patient demonstrated positive outcomes, with improved blood counts and a stable recovery. Nursing care played a central role throughout the transplant process. Key responsibilities included infection prevention, pain management, nutritional support, and monitoring for complications such as GVHD and mucositis. Nurses implemented strict infection control protocols, provided education on self-care and symptom recognition, and offered emotional support. During the post-transplant phase, blood counts were monitored, infection precautions were enforced, and chemotherapy-related side effects were managed. The successful outcome of this case highlights the importance of comprehensive nursing interventions in enhancing patient recovery, reducing complications, and supporting a smoother post-BMT recovery.

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Bone marrow transplantation, multiple myeloma, nursing care.

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The Shiva Purana, a gem among the eighteen principal Puranas in Hinduism, brims with a tapestry of spiritual, philosophical, and cultural tales woven around the enigmatic figure of Lord Shiva. Beyond mere theological and devotional significance, the text unveils a tapestry of profound insights into environmental consciousness, echoing the intricate ecological ethos woven into the very fabric of ancient Indian thought. This research article delves into the intricate environmental themes woven throughout the Shiva Purana, meticulously examining its shlokas, narratives, and symbolic representations to unveil the profound ecological wisdom embedded within. Employing a qualitative content analysis, this study delves into pivotal research inquiries regarding the text's depiction of nature, its significance in the context of contemporary environmental dilemmas, and the tangible ramifications of its insights. The article delves into the intricate limitations and formidable challenges that arise when attempting to interpret and implement these ancient insights within modern contexts, offering a rich and nuanced understanding of the Shiva Purana's significant contribution to environmental consciousness.

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 Keywords

Shiva Purana, environmentalism, sacred ecology, Hindu philosophy, sustainability, forest symbolism, Shaivism, Shiva, nature worship

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