Volume 12 | Issue 8 |

 Abstract

Work and family conflict occurs when there are incompatible demands between the work and family roles of an individual that makes participation in both roles more difficult. The study is about Work-Family Conflict among Nurses in Coimbatore Hospitals. The main objective of the study is to identify the influence of personal profile of nurses on various variables of Work-Family Conflict and to know whether marital status influences the factors of the work family conflict. For this purpose, a sample of 150 is collected from the respondents based on survey method. The statistical tools like Anova and t-test were used for analysing the data. This Study Suggest that generating awareness towards Work Family Conflict may help them to handle it. They can inculcate the art of time management by mentor through some programs. The management can arrange for family tours, picnics or for a get together at periodic intervals. This would help to increase the rapport with the nurses. The hospital management can also provide proper training like different methods to toggle the patients' tension, stress free activities, yoga, etc. The study reveals that Work-Family conflict of nurses is influenced more by work and family role variables. Mostly the Family Social support influences the work family conflict than Work Place support. While taking care of the health of others, it is important that nurses should learn and use the methods and techniques to take care of their own health also.

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 Keywords

Rapport, Time Management, Work Family Conflict

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Abstract: The burgeoning field of personalized pharmacology promises to revolutionize medical treatment by tailoring therapeutic strategies to individual genetic profiles. Integrative bioinformatics, a discipline that combines computational tools and biological data, is at the forefront of this transformation. By leveraging vast datasets from genomics, proteomics, and metabolomics, bioinformatics approaches enable the identification of biomarkers and the prediction of drug responses, thereby facilitating the development of personalized medicine. This paper explores the future perspectives and applications of integrative bioinformatics in personalized pharmacology. It highlights the key technologies and methodologies, such as machine learning, data mining, and systems biology, that are driving advancements in this field. The integration of multi-omics data is emphasized as a critical factor in understanding the complex interactions between genes, proteins, and metabolites that influence drug efficacy and safety. Moreover, the paper discusses the role of electronic health records (EHRs) and real-world data in enhancing the accuracy of bioinformatics models, thus ensuring more precise and individualized treatment plans. Recent advancements in artificial intelligence (AI) and machine learning are also examined, demonstrating how these technologies are being used to predict adverse drug reactions and optimize drug dosages. The application of network pharmacology and pharmacogenomics is reviewed, providing insights into how these approaches contribute to the identification of novel drug targets and the repurposing of existing drugs for personalized therapy. Despite the promising advancements, several challenges remain, including data integration, standardization, and the need for robust validation frameworks. Ethical considerations, such as patient privacy and data security, are also addressed, underscoring the importance of developing transparent and secure bioinformatics systems. In conclusion, integrative bioinformatics is poised to significantly impact personalized pharmacology, offering new avenues for research and clinical practice. By overcoming current challenges and leveraging technological advancements, the future of personalized medicine holds great potential for improving patient outcomes and optimizing therapeutic interventions. This paper provides a comprehensive overview of the state-of-the-art approaches and future directions in integrative bioinformatics for personalized pharmacology, aiming to inform and inspire further research and development in this dynamic field.

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Bioinformatics, Pharmacology, Clinical Practice, Personalized Therapy

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The present research paper is an attempt to make the spatial analysis of availability of household amenities in Patna Municipal Corporation Area. The study is based on secondary source of data, collected from Houselisting and Housing Census Data, 2011. The study reveals that the development of household amenities is higher in central and southern parts of Patna Municipal Corporation area while the northern and eastern part of the city is least developed in this regard

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Household Amenities, Patna, Municipal Corporation Area, ward

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Nanotechnology is relatively a new branch of science that has found a wide range of applications which ranges from energy production to biomedical applications. In present study, ZnO nanoparticles are synthesized using fresh leaf extract Morinda citrifolia by Co-precipitation method. The synthesized nanoparticles are characterized by X-Ray diffraction analysis (XRD), Fourier Transform Infrared spectral analysis (FTIR), UV-Visible spectral analysis (UV-Vis), Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray analysis (EDX) and Antimicrobial activity. From XRD, the particle size of ZnO Nps is determined and is about 15.77 nm. The presence of biomolecules and functional groups are investigated by FTIR analysis. The band gap energy of ZnO Nps is estimated using UV-Vis Spectral analysis and it is approximately 3.31eV. The surface morphology and elemental composition of ZnO Nps is observed under SEM and EDX. The inhibition zone of ZnO Nps is determined by antibacterial activity and results increasing zone of inhibition for various concentration of sample. The ZnO Nps shows moderate activity against HT-29 cell lines.

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Nanotechnology; Green synthesis; Zinc oxide nanoparticle; Morinda citrifolia; antibacterial activity; anticancer activity

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Elections were fundamental to democratic governance. Issues such as voter turnout, engagement, and generational preferences impact electoral outcomes. The significance of millennial participation had drawn attention, both globally and in the Philippines. The study examined the voting behavior and preferences of millennials in Tarlac City, revealing key demographic insights and their impact on electoral choices. The study used quantitative correlational research to explore connections between variables like demographics, voting behavior, and preferences among millennials in Tarlac City. Data collection involved questionnaires, interviews, and documentary analysis. The respondents were randomly and conveniently selected to get a diverse sample, and the data were analyzed using statistical tests and software to find patterns in millennials' preferences and behaviors when voting. The research highlighted personality traits, particularly thoughtfulness, as crucial in candidate selection. Security platforms were the primary concern for voters. The political or family background of candidates significantly influenced millennial voting behavior. Social and peer pressure affected the respondents. Governance skills and leadership style were highly valued in candidates. And traditional campaign methods, like rallies and caucuses, were preferred. The study found significant correlations between various demographic profiles and voting behavior. Age, gender, education, marital status, occupation, and religion all play critical roles in shaping political preferences. Addressing election challenges, such as vote buying and procedural issues, was essential for ensuring a fair and inclusive electoral process. It is recommended to target millennials with voter education campaigns, modernize electoral processes with technology, and provide additional precincts. They may establish monitoring systems to assess interventions and campaign managers to commit to ethical practices and use innovative tactics to engage millennials were also recommended.

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Voter engagement, voting behavior and preferences, election, Millennials voting patterns

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ADJUSTMENT AS ACHIEVEMENT Adjustment as achievement means how efficiency an individual can perform his duties in different circumstances. Coob (1972) examined the relationship between the frequency of a specific task oriented behaviour and academic achievement in fourth grade children. The results obtained are that over task oriented and social behaviour in the class room may be an important academic progress.

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Adjustment Problem , Secondary Student

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This research article explores the intricate aspects of school climate in secondary education, specifically for secondary level. It examines the various challenges that influence the educational setting and acknowledges the critical role of school climate in shaping students' academic and personal growth. The study seeks to pinpoint and assess the main issues affecting this environment and offers potential solutions to address them. Secondary school years are a critical period in students' lives, influencing their well-being, academic success, and overall school experience. This research highlights several pressing concerns that contribute to an unfavorable school climate. Among these are the high rates of bullying and peer conflicts, which create an unsafe and unwelcoming atmosphere. The study also addresses the social and emotional difficulties faced by adolescents, such as mental health challenges, the need for supportive relationships, and the importance of fostering a sense of belonging. Additionally, the research explores how school leadership and teacher-student relationships influence the school climate. It underscores the importance of effective communication and collaboration among all members of the school community to improve the overall educational experience. By examining these issues and proposing solutions, the study aims to help schools create a more positive and supportive environment for their students.

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School Climate, Secondary level, Teachers, Students, Perspectives, Remedies.

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Pharmacokinetic properties are widely connected in the form of oral dose, to treat different kind of disease. This type of formulation is very quickly eliminated through the body so it became very challenging work to maintain the therapeutic effect. Some of medication work locally in gastric problem but it last very few times in the stomach. Now a days very different studies have been done to point out the formulation which can increase the drug lasting time in stomach. More increase stomach retention time of the dosage form, different kind of approaches are done, one such approach is the development of gastro retentive controlled drug delivery. It useful for many more drugs that are orally administered. GRDDS is a type of novel drug delivery system it increases the gastric residence time of the formulation, increase the bioavailability of the drug and used different kind of gastric related disease. GRDDS approaches, the factors affecting the gastric retention, advantages, and disadvantages are briefly discussed. Method for development of the Gastro-retentive Multi particulate System, Comparison of conventional and gastro retentive drug delivery systems, assessment of gastro retentive dose forms, use of polymeric material in gastro retentive formulations.

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Bioavailability, floating systems, gastroretective drug delivery systems, gastric transit time, raft systems, hydrogels.

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Hypophysation, also known as hypophyseal injection or induced breeding, is a technique used in aquaculture to induce spawning in fish species, including Cyprinus carpio (common carp). This method involves the administration of hormones to stimulate the reproductive system of fish, leading to the release of eggs and sperm. This technique is an artificial induced breeding technique. Cyprinus carpio are induced to spawn by the injection of pituitary extract. Hypophysation is a technique of induced breeding in Cyprinus carpio by injecting pituitary gland extract. In this method the pituitary gland extract is injected into intramuscular/pectoral fin region of fish. The gland stimulates the development of gonads which helps fish to breed. When the pituitary gland of the same species is used, its referred as homoplastic injection method. Induced breeding is practiced in a wide variety of species, with this technique we can produce fish seed in large number in all seasons. With this technique we can produce hybrid varieties of species. This technique shows accurate fertilization (78-85%) and Hatching rate (70-85%) this present study reveals the process engaged in Hypophysation technique.

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 Keywords

Pituitary gland, Cyprinus carpio, Fertilization, Hybrid varieties, Homoplastic

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Creative Commons Attribution 4.0 and The Open Definition