Volume 9 | Issue 8 |

 Abstract

In this study, novel 1-(2-methyl)-1, 3-dioxalan-2yl)piperazine derivatives were designed. Designed derivative compounds against 1EVE molecular docking simulation was carried out with Mcule and Insilco ADME Prediction Procedures. The results of docking study revealed that the binding profile for designed derivative compounds M4, M5, M6, M7, and K6 was found significant interactions with Donepezil with catalytic active site (CAS) of 1EVE. The predicted ADME properties revealed that all compounds fulfil drug-like criteria and could be considered as good candidate for drug development. All the designed compound derivatives have Standard Drug (Donepezil) like ADME properties.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

1-(2-methyl)-1, 3-dioxalan-2yl)piperazine derivatives, 1EVE, Mcule, Insilco ADME Prediction, molecular docking, catalytic active site (CAS).

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Hand dominance, Grip strength, Dynamometer.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Jassids are also scientifically known as Apheliona maculosa. The pests suck sap from the leaves and stems and have green appearance. Due to the suction of sap the margin of leaf starts becoming yellow which is a characteristic feature to identify the plants infected by Apheliona maculosa. In severe cases the foliage turns yellow and then dries and falls of. Yield loss of Glycine max due to the pests is approximately 40-45%.. When the crop age is 35-40 days then dimethoate is sprayed i.e. 30 EC @ 2ml /lit. This can be repeated after 15 days if it is required. Except that oxydemeton methyl 25 EC @2ml/lit or 0.05 % quinalphos 25 EC @ 2ml/lit can be sprayed. Although chemicals protect the yield but they are harm the environment. So for the sake of environment, bio-pesticides should be adopted now. The present study has the following extracts that may be used as bio-pesticide, i.e. Curcuma longa and Nigella sativa. At an interval of 1 week these extracts were used for 4 days for checking their efficacy against Apheliona maculosa. When results were observed it showed that Nigella sativa was more effective with mortality of about 74.35% and Curcuma longa with only 63.69% of mortality. However Curcuma longa showed fewer efficacies than Nigella sativa. Damage % on Glycine max after application of 1st , 2nd , 3rd and 4th round of Curcuma longa was 2.38, 2.67, 2.93 and 3.02 whereas for Nigella sativa it was 2.24, 2.62, 2.84 and 2.92. Percent infestation was reduced when Nigella sativa was used.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

curcuma longa, nigella sativa, glycine max, comparative study,as Apheliona maculosa

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Psoriasis is one of the commonest skin diseases characterized by scaly papules and plaque. People with inflammatory bowel disease such as Crohn disease or Ulcerative colitis are at an increased risk of developing Psoriasis. Psoriasis is about five times more common in people of European descent than in people of Asian descent. Our system of medicine provides better outcome over many Autoimmune diseases and one among that is Psoriasis

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Psoriasis, Homoeopathy

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

In metallurgical plants the blooming mill is an intermediate link between the steel-casting shops and the rolling shops, which turn out the finished product. Blooming mill department, in that one of the major issue is frequent host failure in roller conveyor the cooling water supplying through hoses should be in proper working condition because it helps in maintaining microstructure of steel properly. Hence we analyzed the causes of hose failure and we modified the hoses and replaced it wherever necessary.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Blooming mill, rolling mill , steel

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Digital technology Muslim women, Digital Literacy

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Feminism, Henry Ibsen, Nora, Feminist, Women, equality, society, family, Patriarchy

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

this papa

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

google cloud platform,recovery point object,recovery time object

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Utilization of agricultural residues is often difficult due to their uneven and troublesome characteristics. The process of converting biodegradable residuals into a compressed block by compacting is known as briquetting. There are different machine available in market to compact residuals but those machine are bulky and are costly, hence here we designed a portable, economical briquetting machine, which uses scotch yoke mechanism to convert the biological waste into useful briquette. This study is based on production of such briquettes using biodegradable waste (rice husk) and to analysis its physical parameters (Total Solid, Calorific Value) and Proximate parameters (Percentage Moisture Content (PMC), Percentage volatile matter (PVM), Percentage ash content (PAC), Percentage fixed carbon (PFC)) of such briquettes and compared with standard coal briquette.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Agro-residues, Briquette, Proximate Analysis, Densification, Scotch Yoke Mechanism.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

: Metal in the structure of sheets is paramount in the manufacturing industry. Its functions are countless. But metallic in the structure of sheets can't be immediately used, operations like cutting, punching, blanking, bending, trimming, etc. are wished to be carried out on the metallic sheets in order to thoroughly make use of them. For these operations, most large-scale manufacturing industries use hydraulically operated machines. But on account that hydraulic machines are no longer cost- effective, most small and medium scale industries use hand-operated machines for carrying out sheet steel operation. The trouble with hand-operated machines is that are gradual and can't be automated. This is the place the idea of pneumatics will show itself advantageous. It is a guide technique so that sheet metals are to be wasted someday due to the fact of errors befell such as incorrect dimensions etc., and additionally even a easy reducing might also take lengthy time. Hydrau- lic machines are additionally accessible for sheet metallic cutting. But this technique is used for solely heavy metallic slicing and its value is very high. We are the use of a pneumatic device for sheet metallic slicing in an convenient way. It is operated by means of a pneumatic hand lever of two-way manage valve. Control valve is operated through a compressor. Hydraulic machines are additionally used for sheet metallic cutting. But these machines are used for heavy metallic slicing and its price is very high. Hence, we are the use of a pneumatic device for sheet metallic reducing in a handy manner. The principal gain of pneumatic sheet metallic slicing desktop is to enhance product quality, repetition of work and growing manufacturing rate.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Hydraulic, Pneumatic, FRL unit, Double Acting Cylinder. DCV, Pressure Relief Valve etc.

  License

Creative Commons Attribution 4.0 and The Open Definition