Volume 11 | Issue 7 |

 Abstract

The current study's goals are to provide a quick, accurate UV absorption spectrophotometric method for measuring medicines with low water solubility, such carvedilol, in pharmaceutical formulations and to assess cavtedilol's improved solubility in the formulation. By utilising the hydrotropy principle, the aqueous solubilities of these chosen model pharmaceuticals were significantly (5 to 98 fold) increased in distilled water. Ammonium acetate (6M), potassium acetate (5M), potassium citrate (0.5 M), sodium citrate (1.25 M), and urea (8M) are some of the different hydrotropic agents that can be utilised. Sodium lauryl sulphate and Sodium hydroxide are the least expensive and safest solubilizing agent utilised here. The main goal of the current study is to use this solubilizing agent instead of more expensive organic solvents to extract and dissolve the pharmaceuticals from their dosage forms. Because sodium lauryl sulphate and Sodium hydroxide did not exhibit any absorbance at the chosen maximum wavelength for carvedilol, 241 nm and valsartan 250 nm, there was no interference with the estimation. The analysis's findings have been supported by statistical analysis and recovery studies. The suggested approach is fresh, uncomplicated, economical, accurate, secure, and exact. Recovery investigations confirmed the accuracy and precision of the developed methodologies that were applied in accordance with the International Conference on Harmonisation (ICH) principles. Increasing the aqueous solubility of insoluble and slightly soluble drugs is of major importance. Various organic solvents like methanol, chloroform, alcohol, dimethyl formamide, and benzene have been employed for the solubilization of poorly water soluble drugs for spectrophotometric estimations. Drawbacks of organic solvents include higher cost, toxicity, pollution, and error, in analysis due to volatility. In the preliminary solubility studies, it was found that there was considerable enhancement in the aqueous solubilities

Licence: creative commons attribution 4.0

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Hydrotropic, Spectrophotometric estimation, Carvedilol, Sodium lauryl sulphate.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The levels of participation in either of the NGO and GO implemented Water Resource Management areas are not satisfactory, because of some socio- cultural, economic, institutional and physical, technical factors. However, the NGO made Water Resource Management performed comparatively, well. In this regard, several variables are identified for determining the reasons for non-participation. Even though thPrere have been many policy changes in the implementation of Water Resource Management programmes along with the decentralization of power and resource management, there is little awareness about the causes affecting the level and collective action to manage Water Resource Management resources. Under a diverse socio-economic condition, setting up any new institution and have people's involvement is a very challenging task. It is not easy to convince all the beneficiaries to participate within a given period. If the community participation is to be institutionalized, especially over the long run it is essential to rationally analysed the variables affecting community participation.

Licence: creative commons attribution 4.0

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Factors Affecting the Community Participation in Water Resource Management Development Programme and Aquaculture Management in Odisha as a Doctoral Study

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Creative Commons Attribution 4.0 and The Open Definition