Volume 9 | Issue 6 |

 Abstract

Hypermethylation is an important process of gene regulation. Gene silencing through methylation occurs through the activity of DNA methyltransferases, enzymes that transfer a methyl group from S-adenosyl-L-methionine to the carbon 5 position of cytosine. DNA methylation levels and aging are strongly linked. The general trend seems to be the establishment of global hypomethylation and regions of CpG-island hypermethylation with age. Speculatively, this overall decrease in 5mC content could lead to less efficient gene regulation, and the CpG island hypermethylation could cause inappropriate silencing of specific genes. Aging and age-related diseases include defined changes in 5-methylcytosine content and are generally characterized by genome-wide hypomethylation and promoter-specific hypermethylation. In this review promoter hypermethylation in different aging genessuch as GSTP1,p16, p14 RASSF1A,ESR1,GSTP1,NKX2-5 and APC has been discussed.

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 Keywords

Promoter Hypermethylation of Genes In Aging

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 Abstract

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Patient Counselling, Hypertension, Hyperglycemia, life style habits, Drug therapy.

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Emergency alert

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 Abstract

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Marketing, Consumer Behaviour, Buying behaviour, Advertisement, Bhopal

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This study explores the various factors responsible for material cost overrun and the corresponding gap in the estimated and actual material usage. Construction projects in India are often undertaken by Small to Medium-sized Enterprises (SMEs), and are heavily susceptible to an increase in cost from the estimated value leading to the SMEs not being able to arrange for the required additional funds.

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 Keywords

Material Management, Construction, Cost overrun, Gap Analysis, SME Projects.

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 Abstract

Framed reinforced concrete structures are most commonly types of structures constructed all over the world due to ease of construction and rapid progress of work. Generally, brick or block work masonry is done in these frames which act as an infill panels in the framed structure. Infill walls provide the lateral stiffness to the structure. Its behaviour is very different from the bare frame structure.in this research we are trying to find the structural behaviour of Rcc structure when subjected to lateral loads and applying the bracing with changing the position of infill we observe that the position makes a huge difference in structural behaviour. nowadays typical structures with irregularities in it becomes a trend to change the infill with glass panel. our is to find the location of infill which is good for structure and its stability. Methods adopt here by taking the different type of structure like T-shaped and inverted T-shaped structure and applied different positions of infill to check the effects on structure. The results of this is compared with the bare frame and we observed that the bare frame shows maximum deflection, reduction in stiffness, story drift maximum. Infill in the structure shows comparative stability in the structure. As per our results we can suggest the stable positions of infill our aim is to provide the best possible positions of infill in irregular structure.

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 Keywords

multistore structure, role of infill, masonry infill, modelling parameters, story response evaluation

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 Abstract

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Untouchability, Dalits, Slavery, Identity crisis, casteism, suppression, fatalism, Discrimination.

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Key agreement protocol, symmetric balanced incomplete block design (SBIBD), data sharing, cloud computing

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 Abstract

बालक देश के विकास के मजबूत स्तम्भ होते हैं । इनका मजबूत होना समाज के लिए आवश्यक हैं l लेकिन दुर्भाग्य हैं की तमाम नीतियों के होने के बाद भी बालकों की आबादी का एक बड़ा हिस्सा बाल श्रमिक के रूप मे कार्य करने के लिए मजबूर हैं l इसके कई कारण हैं लेकिन जानने के बाद भी कुछ विशेष सफलता बालश्रम को रोकने मे नहीं मिली हैं l प्रस्तुत शोध पत्र द्वितीयक स्रोतों पर आधारित हैं l

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बाल श्रम ,गरीबी ,यूनिसेफ़ ,शोषण ,सीजनल, शहरी वातावरण

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Bricks are mostly used in construction throughout the world. Traditional bricks are made up of clay which is treated in high temperature kiln firing. The removal of top layer of the soil and clay from the resources cause soil erosion. The conventional technique of masonry bricks production has caused severe environmental pollution due to the massive emissions of greenhouse gases which lead to several climate changes such as haze, fog, air pollution, acid rain and global warming. Consequently, the main objective of this paper is to study the development of eco-friendly interlocking bricks for masonry applications by incorporating silica fume. Interlocking bricks are the enhanced form of conventional clay bricks. Each brick is constructively designed to lock itself to the other bricks around without the use of mortar. The self-locking is achieved using shear-key and lock mechanism. Based on the design, the shape of shear-key will vary and a complimentary lock is provided on the opposite side of brick. Load transfer is achieved by shear transfer and gravity. Silica fume is a by product of producing silicon metal or ferrosilicon alloys. One of the most beneficial uses for silica fume is in concrete. Because of its chemical and physical properties, it is a very reactive pozzolan. Partial replacement of cement with silica fume in interlocking brick by 5%, 10%, 15%, 20%, 25%, 30% were used in this study. Compressive and Water absorption test, Block density was conducted to find out the characteristic changes.

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 Keywords

Self locking, shear key, ferrosilicon alloys, pozzolan, block density.

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