Volume 12 | Issue 6 |

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Keywords: Trauma, Road accident, Abdomen, Surgery, Injury.

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Nutraceutical are the current trends on the Pharmaceutical and medicine. Nutraceutical are the combination of Pharmaceutical and nutrition. Nutraceutical posses the biological active compounds which plays a significant role in the maintaining health but also very helpful for the treatment of chronic disease as well. Nutraceutical are helpful in maintaining the healthy daily life. Nourish Nutri fusion is an type of product which helpful for maintaining daily life help and prevent from the sedentary lifestyle diseases. Nutraceutical also provide extra support to the therapy for the chronic diseases. Increased awareness about the relationship between food and health are constantly persuading more people to incorporate the benefits of nutraceuticals into their health regimen. General health trends, lifestyle, disease status and aging population are among the major governing factor influencing the growth of the nutraceutical market.

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Active compounds, Chronic disease, Lifestyle, Sedentary.

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This research focuses on creating and validating a HPLC method to concurrently measure Tamsulosin HCL and Fexofenadine in pharmaceutical products. The method development involved optimizing chromatographic conditions using a Symmetry C18 column and a mobile phase composed of Buffer, Methanol, and Acetonitrile (BMA, 50:10:40, pH 5 adjusted with OPA). These conditions resulted in well-defined peaks with satisfactory separation and symmetry for both substances. Validation of the method included assessing linearity over a concentration range of 4+1800 to 12+5400?g/ml for each compound, demonstrating strong correlation coefficients (R^2 > 0.999). Specificity testing confirmed that there were no interferences from excipients, ensuring precise quantification of the drugs. Accuracy studies showed recovery rates between 95-103%, indicating the method's reliability in determining drug concentrations. Precision studies revealed low %RSD values (<2%) for both intra-day and inter-day variability, indicating excellent repeatability and reproducibility. The method's sensitivity was assessed with LODs of 0.36?g/ml for Tamsulosin HCL and 163.75?g/ml for Fexofenadine, and LOQs of 1.08?g/ml and 496.20?g/ml, respectively. The developed RP-HPLC method was successfully applied to analyze a synthetic mixture containing Tamsulosin HCL and Fexofenadine, confirming its suitability for routine quality control analysis in pharmaceutical formulations. Overall, this method provides a reliable approach for accurate and precise quantification of Tamsulosin HCL and Fexofenadine in complex matrices.

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RP-HPLC, Tamsulosin HCL, Fexofenadine, Method development, Method validation

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Tourism Entrepreneurship: It's Role in Socio-economic Development of Western Assam. Dr. Phatik Chandra Kalita associate Professor HOD. Department of Commerce Bongaigaon College, Bongaigaon. Assam. Email: reachphatikkalita@gmail.com Tourism industry is considered as one of the oldest and is the largest and fastest growing industry in the world. Tourism is a multi dimensional industry which is characterized by the sectors like transportation, communication, tourist guide, hotel and restaurant etc. There are number of segments in the tourism entrepreneurship, like eco-tourism, green tourism, techno-tourism, agri-tourism, home based tourism (HBT), health tourism, religious tourism, educational tourism, cultural tourism, adventured tourism etc. The tourism and travel industry in the world has been dominating by the Europe and United State of America (USA). In a study it is found that almost half of the world tourists every year come from these two countries. The Tourism entrepreneurship has got higher priority in the development agenda of India after the inclusion of it in the General Agreement on Trade in 1994 (World Trade Organization, 2002). In India, this industry's direct contribution to the GDP is expected to record an annual growth rate of 10.35% between 2019 and 2028.The transformation process of the Indian economy has already been started from public sector to the private sector and further pro-poor (PPT Participation) to Public Private Participation. As a result of globalization and liberalization of the Indian economy it has been observed that there are radical changes in the service sector particularly in the tourism sector during the last two decades. The state of Assam is the gate way of the entire north eastern states and the South East Asian Countries. Geographically the state is divided in to three segments like, Upper Assam, Lower Assam and Uttar Assam or north bank of Brahmaputra River.. The Lower Assam or Western Assam is well connected with the other parts of the country as well as the other states of the North Eastern Region. The entire Lower Assam or the Western Assam is full of natural beauty and tourist attraction spots. The present study is trying to highlight the probable prospects and opportunities for tourism entrepreneurship and its contribution to the economic development of the region.

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Key notes: Entrepreneurship, Tourism, Western Assam and Socio-economic Development.

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Mutual funds have become really popular in India as a top choice for investment, mainly because they offer professional management and portfolio diversification. This report focuses on the Securities and Exchange Board of India (SEBI) and its role in regulating the mutual fund sector in India. It gives a historical overview of mutual funds in India, starting from the Unit Trust of India (UTI) in 1963 and leading up to the current situation with rapidly growing assets under management (AUM). The report highlights SEBI's regulatory framework and its vital role in shaping the mutual fund industry, aiming to ensure investor protection, accountability, and transparency. It delves into SEBI's actions, such as regulatory reforms, investor education programs, and grievance redressal systems. Previous research contributions include analyzing the effects of SEBI regulations on industry growth, investor protection laws, ethical standards, transparency, and disclosure norms. By examining SEBI's regulatory framework and its effectiveness in creating a secure and transparent investment environment, this study attempts to clarify the complex dynamics of the Indian mutual fund industry. The study's objectives include assessing the regulatory structure of SEBI, examining investor protection policies, and assessing the impact of SEBI's initiatives on investor confidence, decision-making, and market integrity. The knowledge gained in this study will be useful in comprehending the subtleties of SEBI's regulatory framework and how it affects stakeholders in the industry and investors in mutual funds.Additionally, it provides recommendations for improving regulatory frameworks, addressing challenges, and seizing opportunities to sustainably advance the mutual fund sector in India

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Mutual Funds, SEBI, Investor's Protection

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Over the past two decades, e-commerce, or the computerized purchase and sale of products and services, has grown rapidly. This phenomenon has had a significant impact on traditional brick and mortar retail establishments. With a focus on many factors that affect their strategies, operations, and overall profitability, this study intends to analyze the multiple effects of e-commerce on offline retail firms. We can learn a lot about how the dynamics between these two retail paradigms are changing the way the retail business is organized-commerce, short for electronic commerce, has revolutionized the way businesses and consumers engage in buying and selling goods and services. This digital phenomenon encompasses a wide array of online transactions, from major corporations selling products globally to individuals offering their services on freelance platforms. E-commerce's allure lies in its convenience, enabling people to shop and conduct business from virtually anywhere at any time.

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E-commerce, offline retail business, Online transactions. Global Economy.

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This proposal describes the arrangement based on the Einstein de-Haas experiment. An externally applied magnetic field magnetized the ferrite core by giving microwave power frequency to the coil around the ferrite core. Ferromagnetic resonance is achieved due to the effect of the interaction of spin precession magnetic moments due to Zeeman splitting on the macroscopic magnetization of the material. The core attains negative permeability at ferromagnetic resonance. Due to negative permeability, the ferrite counteracts the magnetizationdue to the applied DC electric field given to one end of the ferrite core. In certain scenarios, negative permeability can lead to the expulsion of the magnetic field resulting in B equal to zero inside the material. This induced phenomenon is somewhat analogous to the Meissner effect observed in superconductors. In the case of negative permeability, the negative magnetic response effectively shields the material's interior from external magnetic fields. The curl of the magnetic field is zero resulting in a net force equal to zero on the moving charge carriers.

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ferrite,FMR,negative permeability,superconducting state

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The objective of this study is to formulate and evaluate poly-herbal shampoo for cosmetic purpose from herbal ingredient such as Hibiscus powder, Neem powder, Henna powder, Amla powder, Shikakai powder, Ritha powder, Alo-vera gel was procured from local market in powdered form also gel form Banyan root powder and Soya milk is prepared by homemade method, then prepared decoction of these ingredients and mixing with each other and evaluated for its organoleptic and physio-chemical characteristics. Herbal shampoo is used to cleansing of the hair also conditioning, smoothing, of the hair surface, good health of hair, hair free of dandruff, dirt grease and lice above all, it's safety benefits are expected. The advantage of herbal cosmetics is their non-toxic nature, reduce the allergic reactions and time tested usefulness of many ingredients. Thus in present work, we found good properties for the herbal shampoo and further optimization study benefits of herbal shampoo on human use as cosmetic product. The aimed to formulate and evaluate herbal shampoo because synthetic may causes the adverse effect on hair and scalp. The herbal shampoo was formulated by Amla powder, Shikakai powder, Ritha powder also addition of preservative agent. Citric acid used as viscosity modifier and pH adjusting agent and glycerin used as conditioning agent.HPMC (hydroxyl propyl methyl cellulose) used as thickening agent. The formulation at laboratory scale was done and evaluated for number of parameters such as pH, foam formation, viscosity, conditioning and wet ability were evaluated, and also to ensure its safety and efficacy.

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Cosmetic, Herbal shampoo.

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Background & Introduction-Ageing is an irreversible process; the effects of a sedentary lifestyle are very evident in most people due to inactivity. When physical capacity falls below the ability required for the performance of daily tasks, functional limitations and a loss of independence may occur. Hence aim of the study is to see the Effect of functional exercises versus conservative treatment on pain, function and hand grip strength in elderly Subjects. METHODOLOGY-This experimental study was conducted on 30 male and female subjects (aged above 60 years) without any severe illness. 30 subjects were divided into 2 groups, Group A was taught functional tasks exercise and Group B was taught conservative exercise for dominant hands, three days per week for total of 4 weeks. For the outcome measures, Hand functions was evaluated through Michigan hand outcome questionnaire and grip strength was measured using handheld dynamometer. Statistical analysis & Result - The data collected was tabulated and data analysis was done by using the IBM SPSS software version 26 and Microsoft excel was used for graphs .The mean and standard deviation of all the variables were analyzed. Non parametric test were used since the data was not normally distributed and the result were considered significant if p<=0.05. There was significant effect in pre and post mean values of functional tasks exercise group and conservative exercise groups on grip strength ,functions in dominant hand (p<=0.05) . But on comparing the mean difference values of hand grip strength and Michigan Hand Outcome measure score between both the functional tasks exercise (Group A) and conservative exercises (Group B), functional tasks exercise shows more significant effect in improving the grip strength and hand functions in elderly subjects. Conclusion- Both functional tasks exercise group (Group A) and conservative exercise group (Group B) have significant effect on improvement on hand function and grip strength in elderly subjects. But statistically, functional tasks exercise shows more significant effect in improving the grip strength and hand functions in elderly subjects.

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- functional exercises, Resistance exercises, hand function , grip strength

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Introduction: Ankylosing spondylitis (AS) is an inflammatory condition of uncertain etiology that primarily affects the axial skeleton, but peripheral joints and extra-articular structures are frequently associated. According to the Siddha Classical Literature on Disorders of the Body and Mind, Yuhi Vaidya Chinthamani 800, the disease Thandaga Vatham, which is characterized by symptoms of pain, bodily stiffness, profuse perspiration, yellowing of the urine and feces, pallor, curving of the spine, diarrhea, and chest congestion, is closely related to AS. Case Presentation: A 23-year-old female, diagnosed with HLA-B27 positive AS, visited the Outpatient Block, Government Siddha Medical College Hospital, Chennai, with concerns of pain while walking, trouble bending forward, and restricted hip joint movement for the past six months. Discussion: The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), and the Bath Ankylosing Spondylitis Metrology Index (BASMI) have been used as standard techniques to assess the disease activity and quality of life of the patients. Thandaga Vatham (AS) was diagnosed, and Siddha treatment was provided for 48 days (1 Mandalam), which included Chitramutti Matakkut Tailam Peechu, Venn Kungiliya Ottradam, Thazhuthazhai Ilai Vedhu (external medication), Vatha Ratchasan Mattirai, Maha Vallathi Ilakam, and Agni Churanam (internal medication). Conclusion: Following the intervention, the patient's signs and symptoms were greatly reduced, and her quality of life improved. The combination of external and internal intervention with Siddha medications appears to be effective in treating AS patients. This study serves as a basis for further research projects on AS.

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Ankylosing Spondylitis, Siddha, Thandaga Vatham.

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