Volume 12 | Issue 12 |

 Abstract

This reseach focused on the formulation and evaluation of mouth dissolving film containing extracts of ocimum tenuiflorum and glycyrrhiza glabra. The ocimum tenuiflorum is commonly known as Holy, basil, tulsi or tulasi. The fixed oil of Tulsi have considerable antiulcer action. The glycyrrhiza glabra commonly known as liquorice. Licorice root extract has healing property and it is used to treat mouth ulcer. The different polymers has different drug release effect in the mouth dissolving film. Mouth dissolving fim can treat the different types mouth ulcers like canker sores, leukoplakia. These films are prepared by solvent casting method. These films have several advantages over normal conventional dosage forms. They deliver the drug at target site so dose frequency is reduced, it avoids the hepatic first pass metabolism and due to this the bioavailability is enhanced. These films are evaluated for it's thickness, morphological properties, folding endurance, surface PH, Disintegration time, stability studies.

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Ocimum tenuiflorum, Glycyrrhiza glabra, mouth dissolving film, polymer, solvent casting method.

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Creative Commons Attribution 4.0 and The Open Definition

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Abstract This paper examines the poetic oeuvre of Imtiaz Dharker through the lens of diaspora, focusing on themes of borders and belonging that permeate her work. Dharker's poetry engages deeply with the fluidity of identity, exploring the tension between cultural heritage and personal autonomy. By dissecting her nuanced portrayal of physical and metaphorical borders--geographic, linguistic, and emotional--this study highlights her ability to navigate the complexities of diasporic existence. Through close readings of selected poems, the paper investigates how Dharker redefines concepts of home and belonging, often subverting traditional notions of rootedness. Her work becomes a space where multiple identities coexist, reflecting her transnational life experiences. Additionally, the paper explores how Dharker's poetic voice resists singular definitions, embodying a multifaceted diasporic perspective that bridges gaps between East and West, tradition and modernity. Ultimately, this study situates Dharker within the broader discourse of diasporic literature, emphasizing how her work challenges fixed boundaries and celebrates hybridity. Her poetry not only articulates the dissonance of displacement but also envisions new forms of belonging, making her a vital voice in contemporary global literature.

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 Keywords

Keywords- heritage, transnational, rootedness, multifaceted, diasporic , hybridity ,displacement

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Creative Commons Attribution 4.0 and The Open Definition

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Nerve pain is a significant health issue in India, primarily driven by conditions like diabetes, infections, trauma, and cancer. Despite its high prevalence, diagnosing and managing neuropathic pain remains challenging due to under recognition, limited resources, and cultural factors. The S-LANSS Pain Score (Self-Reported Leeds Assessment of Neuropathic Symptoms and Signs) is a simple, cost-effective, and reliable tool for identifying and assessing neuropathic pain. This article reviews the burden of neuropathic pain in India, the challenges in diagnosis, and the utility of the S-LANSS Pain Score in clinical practice, highlighting its potential to improve early diagnosis and treatment outcomes.

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Nerve Pain: A Review in the Indian Scenario with Usefulness of S-LANSS Pain Score in the Assessment of Nerve Pain

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As we know every two in five persons suffer from Kadara once in their lifetime and people do not consider this seriously until and unless it starts abruption their daily activities and then reach a doctor when it needs to be seriously considered with the provoked signs and symptoms.[1] Acharya Sushruta describes Kadara under Kshudra roga and its ayurvedic approach of Ksharakarma, Agnikarma, Shastra karma,Lepana karma.[2] Amongst which Agnikarma is the most practiced karma amongst all the karmas due to its less chances to recur.[3] Aim: To evaluate the effect of Tamra Shalaka Agnikarma in the management of Kadara. Material & Method: 30 subject's data was recorded in the case report form with complete history, examination and necessary assessment was done. Afterwards the subjects of Kadara were treated with Tamra Shalaka Agnikarma followed by proper post operative care and regular follow ups of the patients were done until the signs of healthy granulation was observed. Results: The results typically involve the removal of the corn, relieving pain, swelling, tenderness, discharge and discomfort associated with it. The area was initially tender or sore after the procedure, but with proper post-operative instructions care of the patients were taken and follow ups to ensure proper healing and prevent the recurrence of corn over time. Interpretation and Conclusion: From all the available treatment modalities of Kadara, it is clear that it may not have a complete cure, as a chance of recurrence may be there. Comparing all treatment procedures, Agnikarma can be considered the most appropriate management of Kadara (corn). It has a significant result, and the chance of recurrence is significantly lower.

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 Keywords

Kadara, Corn, Tamra Shalaka Agnikarma, Kathina

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Creative Commons Attribution 4.0 and The Open Definition

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In this study, we describe the synthesis and characterization of ZnS and manganese-doped ZnS nanoparticles using a simple and cost-effective chemical method with a polyvinyl alcohol (PVA) matrix. This approach is particularly well-suited for the industrial-scale production of nanoparticles. The synthesized materials were characterized through various techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), UV-visible absorption spectroscopy, and photoluminescence (PL) analysis. Notably, the PL spectrum of the ZnS:Mn nanoparticles revealed a peak at 603 nm, which is attributed to the 4T1-6A1 transition of the manganese dopant.

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Nanoparticles, photoluminescence analysis, X-ray diffraction, ZnS

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Creative Commons Attribution 4.0 and The Open Definition

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India, the world's largest democracy, faces critical challenges in its electoral system, including voter fraud, accessibility issues, transparency concerns, and logistical inefficiencies. Blockchain technology, known for its immutability, transparency, and security, offers a transformative solution. This paper explores how blockchain can enhance the Indian voting system, presenting a detailed architecture, its potential benefits, and the challenges of implementation. The study also analyzes global case studies and proposes a phased approach to adoption in India, ensuring scalability, inclusivity, and trust.

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Creative Commons Attribution 4.0 and The Open Definition

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Blockchain Technology, Indian Electoral System, Digital Voting, Election Transparency, Voter Security, Decentralized Ledger, Immutable Records, Remote Voting, Electoral Reforms, Smart Contracts

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Creative Commons Attribution 4.0 and The Open Definition

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Urinary tract infections (UTIs) are prevalent, especially among women, and are often recurrent. This review explores the potential role of cranberry juice in UTI prevention, focusing on its primary active compounds--proanthocyanidins (PACs)--and their anti-adhesive properties against Uropathogenic Escherichia coli (UPEC). PACs inhibit bacterial adhesion to the urinary tract line, which may reduce infection rates. While clinical trials have reported mixed results, certain studies suggest a beneficial effect of cranberry products in lowering UTI recurrence in high-risk populations. This review discusses cranberries's active constituents, mechanisms of action and clinical efficacy, as well as limitations in current research, including variability in cranberry product formulations and dosages. Given concerns over antibiotic resistance, cranberries could serve as a non-antibiotic prophylactic option for UTI management.

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 Keywords

Proanthocyanidins (PACs), Anti-adhesion, Escherichia coli (E. coli), UTI recurrence prevention, Biofilm inhibition, Natural remedies for UTI, Cranberry PACs mechanism of action, Antibiotic resistance.

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The project presents a Heart Disease Prediction System leveraging a Decision Tree Classifier to identify the likelihood of heart disease based on medical parameters. The dataset includes key features such as age, cholesterol levels, blood pressure, and exercise-induced metrics, which are crucial indicators of cardiovascular health. The system is designed to process these inputs, train the model, and deliver predictions with commendable accuracy. By implementing a Flask-based web application, the solution ensures user-friendly and real-time access to the predictive tool, making it ideal for both healthcare professionals and individuals. This platform can facilitate early detection, enabling proactive measures to prevent severe outcomes. It not only aids in clinical decision-making but also empowers individuals to monitor their heart health. The combination of machine learning and web technologies enhances accessibility, paving the way for efficient, data-driven healthcare solutions. With its robust design, the system contributes to better heart disease risk assessment and management.

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Heart disease prediction, Decision Tree Classifier, Machine learning, Medical parameters, Cardiovascular health, Risk assessment, Real-time predictions, Flask-based web application, Healthcare professionals, Individual health monitoring, Early detection, Preventive healthcare, Data-driven healthcare solutions, User-friendly interface.

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Creative Commons Attribution 4.0 and The Open Definition

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Abstract: The fast fashion industry has revolutionized the accessibility of trendy clothing, fostering a culture of rapid consumption and frequent wardrobe renewal. However, this business model, driven by planned obsolescence and cost-cutting measures, has come at a steep environmental, social, and economic cost. This paper delves into the significant challenges posed by fast fashion, including its contributions to environmental degradation, and micro plastic pollution, as well as its exploitation of labour in low-income countries. The analysis also highlights the industry's reliance on unsustainable practices such as synthetic fibre use, hazardous dyeing processes, and a global supply chain that prioritizes efficiency over ethics. Despite growing consumer awareness and claims of sustainability, the industry remains plagued by opaque practices and a lack of regulatory oversight. By examining the interplay between consumer behaviour, industry practices, and regulatory frameworks, this paper seeks to uncover pathways for a more sustainable future. It emphasizes the urgent need for systemic change, integrating responsible production, ethical labour standards, and informed consumer choices to mitigate the environmental and social impacts of fast fashion while fostering a more equitable global economy.

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Key words: Fast Fashion, Environmental Degradation, Exploitation of Labour, Sustainability Consumer Behaviour

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Creative Commons Attribution 4.0 and The Open Definition

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The New Austrian Tunneling Method (NATM), a versatile tunneling approach, has become a preferred method in complex geological conditions. The Himalaya, due to its unique characteristics present major challenges for tunneling during design and construction phases as it represents an extensive zone of crustal deformation with highly deformed rock masses, unstable slopes and is one of the most seismically active region. In this paper we provide a comprehensive review of the application of NATM in Himalayan geology, and how it has helped to overcome major challenges faced during tunneling. Our findings highlight the flexibility of NATM in handling the dynamic geological conditions of the Himalaya which emphasize the need for continuous monitoring, flexible support systems, and technological advancements to enhance tunnel stability and safety.

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 Keywords

NATM, Himalayan Geology, Tunnel Construction, Geotechnical Challenges, Seismic Activity, Squeezing Ground, Rock Burst, Shear Zones, Fault zones, Shotcrete, Rock Bolts, Stress Monitoring, Hydrological conditions, Adaptive Support Systems

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Creative Commons Attribution 4.0 and The Open Definition