Volume 13 | Issue 12 |

 Abstract

Background: Antibiotics have saved millions of lives and have changed the history of infectious diseases. However, in recent years, antibiotic resistance has become a major problem for global public health. Antibiotic resistance challenges the treatment of common infectious diseases, increases mortality rates and treatment costs. A study was designed to evaluate the effectiveness of structured teaching program on knowledge regarding antibiotics impact on childhood immunity among the parents at selected primary school of Surat, Gujarat with the objectives to 1) assess the knowledge of parents about antibiotics impact on childhood immunity in selected primary school, Surat City, Gujarat. 2) assess effect of structured teaching programmed regarding antibiotics Impact on childhood immunity among parents of Surat City, Gujarat.3) To find out the association of the knowledge of primary school parents regarding antibiotic impact on childhood immunity with their selected demographic variables. Methods: A Quantitative Research approach and pre-experimental one group pre-test post- test research design with non-probability convenient sampling technique was used to collect data from 60 parents of Children (Age group between 5 to 8 years) in selected primary school of Surat, Gujarat. A demographic tool, structured knowledge questionnaire was used to describe the findings. Result: Analysis and interpretation of data collected from 60 samples, on antibiotic impact on childhood immunity and its interpretation among parents of selected primary schools of Surat. Knowledge was assessed by using descriptive and inferential statistics. The data gathered were summarized in the master sheet. Findings revealed that the level of knowledge regarding antibiotic impact on childhood immunity through pre-test and post-test. In pre-test out of 60 parents 34(56.66%) of parents had poor knowledge, 11(18.33%) of parents had average knowledge, 16(26.66%) of parents had good knowledge with regard to post score 5(8.33%) parents had poor knowledge, 15(25%) of parents had average knowledge, 40(66.66%) of them had good knowledge. The paired t-test results t=10.457. Since P-value=2.0015> 0.05 reveals the effectiveness of the Awareness package. The calculated value is higher than the tabulated value. The study aims to assess the knowledge and evaluate the effectiveness of the structure teaching programme on knowledge regarding antibiotics and impact on childhood immunity among parents of primary school children's around 60 samples were selected using Non probability purposing sampling technique. Data was generated and analysed by descriptive and inferential statistics. The paired 't' test value of the study was 19.5 at the significance of 0.05. The calculated value is higher than tabulated (p-value) = 2.00. This shows highly effectiveness of the structured teaching programme among selected samples. Association between pre-test knowledge score with their socio demographic variables regarding antibiotic impact on childhood immunity among parents of primary school children in selected school of Surat. Hence, it was assessed that Age, gender, No. Of children, Education of family, information, occupation, leaving the area does not have any significant association (Age ?2= 7.14, gender ?2 = 5.74, Number of children ?2 = 10.87, Education of head of family ?2= 4.22, Source of Information regarding antibiotics ?2 = 4.26, occupation of family head ?2=10.79, living area ?2= 4.50) and Monthly income ?2= 6.36. Other demographic variables such as Type of Family do have significant association in the study (Type of family ?2= 16.25) Conclusion: The study was conducted to assess the effectiveness of structure teaching program on knowledge regarding antibiotics impact on childhood immunity among the parents at selected primary school of Surat, Gujarat. The finding of the study showed that structured teaching program about antibiotic impact on childhood immunity was effective among parents of primary school children. Association between pre-test knowledge score and socio demographic variables regarding antibiotic impact on childhood immunity among parents of primary school children in selected school of Surat. Hence, it was assessed that, Type of Family and Monthly Income does have significant association in the study.

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 Keywords

Evaluate, Effectiveness, knowledge, Antibiotics, immunity.

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There is no doubt that economic participation of women has increased in India during last few years, but still they are far back in terms of economic independence. The situation is same for both urban and rural women as discrimination is a reality and gender gap is wider in the economic field. Women have more opportunities and facilities in urban areas in comparison to rural areas. Thus rural women should be more conscious and updated but the reality is totally different. They can't reach to the facilities in lack of knowledge and awareness. Trainings were being organised at different level by different agencies but that's not sufficient. Impact of wrong and inadequate training can be seen among self help group members. Lack of sufficient financial services by the service providers, deep rooted social barriers and lack of strong decision making power among the women are equally responsible for their weak financial condition. Full planned financial literacy program along with digital technology education is highly needed. Due to the awareness about micro financing and micro credit schemes rural women have started savings by making self help groups. Savings only for borrowing and lending money among the group members can't be much fruitful. They should know about other use of money. Banking is not all about saving and loaning; investment and insurance is much more important in planning a better future with economic stability. With the help of World Bank, Government of Bihar is working hard to make the rural women financially empowered. Focus is on sustainable job creation at local level so that they can be self dependent. Banking and insurance sector have to come forward with a big heart to train them about making money, as saving for lending and borrowing is not the ultimate option in the process of financial empowerment. The present study was conducted in the rural areas especially pilot blocks of jeevika. Per capita income is very low as compared to other areas thus saving and investment is low. Total sample of 350 SHG members is comprised through random sampling technique. The primary data was directly collected through personal interview method between 2021to2023.

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FINANCE, WOMEN, RURAL, BANKING, EMPOWERMENT

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The quality of education in any society is significantly influenced by teacher effectiveness. This study examines the relationship between teacher effectiveness and enthusiasm among secondary school teachers in Rohtak district, Haryana. Teacher effectiveness encompasses skills like subject knowledge, instructional strategies, and classroom management, while teacher enthusiasm involves passion, energy, and emotional commitment. A sample of 800 secondary school teachers was selected using multi-stage random sampling. The study found a strong, positive correlation between teacher enthusiasm and effectiveness. Teachers with high enthusiasm were significantly more effective than those with lower enthusiasm. Although gender didn't directly impact effectiveness, enthusiastic female teachers slightly outperformed their male counterparts. The study suggests that teacher enthusiasm is crucial for effective teaching and should be fostered through professional development and supportive environments. Educational policies and teacher training programs should emphasize both pedagogical skills and affective dimensions of teaching. By nurturing teacher enthusiasm, schools can enhance teacher performance, student engagement, and overall education quality.

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Teacher Effectiveness and Teacher Enthusiasm.

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Urolithiasis, known as Ashmari in Ayurveda, is a common urinary disorder characterized by stone formation due to metabolic and dietary factors. Ayurveda describes Ashmari as a result of Dosha imbalance, predominantly Kapha, and recommends the use of Ashmarighna, Mutrala, Lekhana, and Bhedana drugs for its management. India has a rich tradition of using medicinal plants for urinary stone disorders, many of which are widely available and traditionally validated. In recent years, experimental studies have provided scientific support for the lithotropic activity of these plants. This narrative and analytical review was conducted using classical Ayurvedic texts, the Ayurvedic Pharmacopoeia of India, and peer-reviewed scientific literature to comparatively evaluate selected herbal drugs. Plants such as Bergenia ligulata, Aerva lanata, Rotula aquatica, Tribulus terrestris, and Crataevanurvala demonstrated significant anti-urolithiatic activity. Their Ayurvedic attributes showed strong correlation with modern pharmacological mechanisms, including inhibition of calcium oxalate crystallization, increased diuresis, nephroprotection, and anti-inflammatory effects. The study highlights convergence between Ayurvedic principles and modern scientific validation, supporting the potential of these herbs in evidence-based management of urolithiasis.

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Ashmari, Lithotropic activity, Antiurolithiatic herbs, Ayurveda, Pashanabheda

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The widespread adoption of digital education platforms has transformed access to learning resources across the globe. However, most existing systems rely on instructor-centric delivery models that limit interaction, personalization, and affordability. This paper presents Learn and Let Learn, an intelligent peer-to-peer skill exchange platform designed to enable users to simultaneously act as learners and mentors. The system employs a hybrid recommendation mechanism combining collaborative filtering and content-based analysis to match users based on skills, interests, and learning objectives. Secure authentication, real-time communication, and automated scheduling enhance user engagement and trust. Experimental evaluation demonstrates improved skill-matching accuracy, higher learner satisfaction, and enhanced knowledge retention when compared with traditional online learning platforms.

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Peer-to-Peer Learning, Skill Exchange Platform, Recommendation Systems, Collaborative Filtering, Web Technologies

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Abstract Procurement of a timely and reliable war-critical weapon system is extremely important for any defence forces to build up their combat potential. But it does not end there. The procured system must continue to deliver its stated performance under various climatic conditions and over varied geographical terrains. The cost associated with sustaining such complex weapon systems adds another dimension during the procurement. Improved operational readiness would be one of the most critical factors to achieve operational excellence, and operational readiness can only be achieved through improved operational effectiveness of our equipment. High reliability in equipment is certainly a desirable function, but so is maintainability and excellent logistic support. A Life-Cycle Sustainment Plan (LCSP) is required to be developed for each capital equipment to be procured henceforth, and included as a part of the acquisition strategy. Keywords: Life Cycle Sustainment, System Approach, Total Cost of Ownership, Operational Readiness, Reliability

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Life Cycle Sustainment, System Approach, Total Cost of Ownership, Operational Readiness, Reliability

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This research paper examines the role of optimized electric vehicle (EV) charging station planning in improving charging efficiency, grid reliability, and cost-effectiveness within urban power distribution networks. By analyzing EV charging infrastructure that supports a growing number of electric vehicles with varying mobility and charging demands, the study highlights how optimal placement and sizing of charging stations reduce travel distance, minimize grid overload, and lower infrastructure and operational costs while ensuring reliable energy delivery. Advanced planning approaches, such as grid-aware optimization and demand-based allocation methods, ensure that charging resources are efficiently utilized without compromising power system stability or user accessibility. The integration of these strategies enables scalable charging infrastructure development, real-time energy management, and dependable support for large-scale EV adoption. The paper concludes that optimized EV charging station deployment is a critical component of sustainable transportation systems, enhancing charging efficiency while ensuring reliability, economic viability, and environmentally friendly mobility for users and energy providers.

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Enhancing Electric Vehicle Charging Infrastructure Efficiency through Optimal Charging Station Placement

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In an era where computing is becoming om- nipresent, relying solely on physical peripherals like mice and keyboards presents real challenges, particularly re- garding hygiene in public spaces and accessibility for users with physical impairments. This paper introduces a contactless Human-Computer Interaction (HCI) system designed to overcome these barriers by merging computer vision with voice automation in a unified, efficient frame- work. Although several existing solutions rely on heavy deep learning classifiers such as CNNs or YOLO, our work demonstrates that a lightweight, geometric approach based on MediaPipe's hand landmarks can achieve comparable accuracy without the high computational cost. A key contribution of this research is the resolution of the "Blocking I/O" bottleneck--a common flaw in Python- based multimodal systems where voice recognition causes the video feed to freeze. We addressed this by engineering a concurrent, multi-threaded architecture that isolates the cursor control mechanism from the voice assistant. This ensures that the mouse cursor remains responsive even while the system is processing complex speech commands. Tests on standard hardware confirmed the system's via- bility, achieving a stable frame rate of over 30 FPS and a gesture recognition accuracy of 94%, making it a practical solution for sterile or accessibility-focused environments.

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 Keywords

Human-Computer Interaction, MediaPipe, OpenCV, Multithreading, Geometric Heuristics, Voice Au- tomation, Contactless Interface, Python GIL.

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Telmisartan, Azelnidipine, Azilsartan, Assay, Degradation studies, RP-HPLC, Validation, ICH guidelines

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drug delivery systems represent a transformative advancement in pharmaceutical science, fundamentally addressing limitations of conventional dosage forms through engineered control of drug release kinetics, pharmacokinetic profiles, and spatial biodistribution. These sophisticated carrier systems encapsulate therapeutic agents within polymer matrices, enabling sustained-release kinetics maintaining therapeutic drug concentrations over days to months from single-dose administration, substantially improving patient compliance and reducing dosing frequency. Polymers serve as intelligent gatekeepers, physically or chemically binding drug molecules while providing protection from degradation in physiological fluids, enhancing bioavailability of poorly soluble compounds, and facilitating targeting to specific tissues through surface functionalization. Natural polymers including chitosan, alginate, and gelatin offer enzymatic degradability and inherent biocompatibility, while synthetic biodegradable polyesters (polylactic acid, polyglycolic acid, polylactic-co-glycolic acid, poly-?-caprolactone) provide predictable degradation kinetics and precise manufacturing control. Emerging stimuli-responsive smart polymers demonstrate dynamic property changes in response to pH variation, temperature fluctuation, or enzyme activity, enabling conditional drug release exclusively at target disease sites. Drug loading strategies span physical encapsulation, chemical conjugation, surface adsorption, and complex coacervation, each optimized for specific drug properties and formulation objectives. Release mechanisms include diffusion-controlled pathways following Higuchi kinetics, polymer erosion and degradation through hydrolytic and enzymatic processes, and stimulus-triggered liberation through physiological triggers. Clinical applications extend across oncology, immunology, cardiovascular disease, infectious disease, and chronic pain management, with over 200 polymeric drug products currently approved globally. Biocompatibility assessment through comprehensive in vitro and in vivo testing ensures safety, while biodegradation pathways ensure metabolic clearance preventing long-term accumulation. Persistent challenges including batch-to-batch reproducibility, long-term stability, manufacturing scalability, and regulatory complexity continue requiring innovative solutions.

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Polymeric Drug Delivery, Controlled Release, Biodegradable Polymers, Stimuli-Responsive Systems, Drug Formulation, Biocompatibility, Therapeutic Applications

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