UNDERSTANDING SYNTHESIS AND BIOLOGICAL ACTIVITY OF PHOSPHINOPHOSPHONATE PHOSPHOANTIGENS

The creation of novel phosphoantigens is desirable for a variety of reasons, including prospective pharmaceutics and research into the mechanism of action of existing phosphoantigens. To this date, the phosphoantigens produced by our software have all been phosphonates, which are compounds containing only one phosphorus. All of the synthetic phosphonates, on the other hand, are less powerful than the naturally occurring HMBPP. Bodec and colleagues examined the utility of a second phosphorus by creating a diphosphonic acid, which they used to test their hypothesis.

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